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Mutual Information in a MEG Complexity Measure Suggests Regional Hyper-Connectivity in Schizophrenic Probands

Neuropsychopharmacology 40
Robinson, S.E.Mandell, A.J. MEG Core Facility, NIMH,
Bethesda, MD, USA

Department of Psychiatry,
UCSD School of Medicine,
San Diego, CA, USA
2014 Biology, Physics

Abnormalities of regional brain functional connectivity have been suggested for the syndromes of schizophrenia since the origin of the name using the Greek roots: skhizein (to split) and phren (mind) by Eugen Bleuler in 1908 (Kuhn, 2004). The neuropsychologist Norman Geschwind generalized this pathophysiological concept in his classic papers about what he called the disconnexion syndromes (Geschwind, 1965).

He suggested that deficits in higher functions resulted from the disruption of pathways involving the signal relay functions of the association cortices. Discontinuities in white matter observed in diffusion tensor imaging and inferences from fMRI have been interpreted as evidence for cortical network disconnections in patients with schizophrenia (Bullmore et al, 1997).

The article was published in: Neuropsychopharmacology 40: 251

Full article

This work was supported (in part) by the Fetzer Franklin Fund of the John E. Fetzer Memorial Trust.