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Calcifying nanoparticles promote mineralization in vascular smooth muscle cells: implications for atherosclerosis

International Journal of Nanomedicine 9
Hunter, L.W.Charlesworth, J.E.Yu, S.Lieske, J.C.Miller, V.M. Department of Surgery,
Department of Biochemistry and Molecular Biology,
Mayo Clinic, Rochester, MN, USA

Lincoln University,
Christchurch, New Zealand

Izon Science Ltd.,
Christchurch, New Zealand

Department of Internal Medicine,
Division of Nephrology and Hypertension,
Department of Laboratory Medicine and Pathology
Department of Physiology and Biomedical Engineering
Mayo Clinic, Rochester, MN, USA
2014 Biology, Physics

Nano-sized complexes of calcium phosphate mineral and proteins (calcifying nanoparticles [CNPs]) serve as mineral chaperones. Thus, CNPs may be both a result and cause of soft tissue calcification processes. This study determined if CNPs could augment calcification of arterial vascular smooth muscle cells in vitro.

The study was published in: International journal of nanomedicine 9: 2689.

Full article

This work was supported (in part) by the Fetzer Franklin Fund of the John E. Fetzer Memorial Trust.